Webb25 maj 2012 · Tigecycline. Trade Names: ... Pharmacokinetics: administered i.v. only (acid labile). Serum half-life is long (42 hours). 60% biliary/fecal elimination. Notes: Many … Webb18 sep. 2024 · A prospective study was designed including critically ill patients treated with tigecycline for multidrug-resistant Gram-negative infections. Blood samples were …
Population Pharmacokinetics of Tigecycline DDDT - Dove …
Webb1 juni 2024 · In 2013, Pai compared the serum and urine pharmacokinetics of tigecycline in class 3 obesity adults and those in normal weight adults and found that the results were … Webb13 juni 2005 · Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence … greengard center portsmouth
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS - European …
WebbTigecycline pharmacokinetics were mostly described by a two-compartment model in these included studies. Estimated clearance and volumes of distribution of tigecycline at … Tigecycline, a first-in-class glycylcycline antimicrobial agent, has an expanded spectrum of activity against gram-positive, gram-negative, aerobic, anaerobic, and atypical bacteria, including strains that are multidrug resistant. It is active against methicillin-resistant S. aureus, penicillin-resistant S. pneumoniae, … Visa mer Glycylcyclines are a novel class of antimicrobial agents, and tigecycline (figure 1) is the first of the glycylcyclines to reach the final stage of clinical development. Tigecycline inhibits translation of bacterial … Visa mer The pharmacokinetic properties of tigecycline have been studied in several animal species. Overall, the pharmacokinetics in animals is characterized by a low … Visa mer The pharmacokinetics of tigecycline, including metabolism and mass balance studies, have been evaluated in healthy subjects and in patients with complicated skin and skin-structure … Visa mer The interrelationship between the pharmacokinetics and pharmacodynamics of antimicrobial agents has become increasingly important. Data from in vitro and in vivo infection models, including dose fractionation … Visa mer Webbaltered by hemodialysis. The pharmacokinetics of tigecycline are also not affected by food, although tolerability is increased if the drug is administered following a meal. … green garden chinese cradley heath