Shoc2 phosphorylation
Web5 Mar 2010 · In the HeLa cells used in our experiments, Shoc2 knockdown was found to affect the level of phospho-MEK and phospho-ERK upon stimulation, particularly at a low concentration of EGF (Fig. 1, B and C).Furthermore, EGF-induced phosphorylation of MEK and ERK was suppressed with a slight delay in Shoc2-depleted cells (Fig. 1, D and … Web10 May 2024 · SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and …
Shoc2 phosphorylation
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Web7.1 SHOC2 is required for MEKi-induced feedback relief RAF dimerization and ERK-activation 108 7.1.1 Introductory statement 108 7.1.2 SHOC2 deletion impairs rebound MEK … WebTo indentify the signal that could trigger SHOC2-Thr507 phosphorylation, we used computer software GSP3.0, which predicts MAP2K1/MEK1 as a kinase for Thr507 phosphorylation …
WebShoc2 module, thereby altering the ubiquitination of Shoc2 and RAF-1 as well as the amplitude of ERK1/2 signals. These studies also show that the levels of Shoc2 ubiquitination and ERK1/2 phosphorylation are imbalanced in fibroblasts isolated from Inclusion Body Myopathy with Paget’s disease of bone and Frontotemporal Dementia Web1 Feb 2024 · Moreover, we found that when expressed in eukaryotic cells as intracellular antibodies (intrabodies), high affinity Shoc2 hs2dAbs altered the amplitude of the ERK1/2 phosphorylation. These results demonstrate the potential of Shoc2 hs2dAbs to selectively target the scaffolding complex and as a tool for development of treatments altering …
Webvia Shoc2 where it dephosphorylates an inhibitory residue Ser259 allowing for activation of RAF-1 by phosphorylation. Further-more, Shoc2 was shown to modulate Ca2+- and … Webphosphorylation by different kinases reverses the activation of RAF molecules. According to our data, the SHOC2 complex is essential for EGF-stimulated RAF heterodimerization and …
WebThe SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling by removing an inhibitory phosphorylation event on the RAF family of proteins …
WebExplore 30 research articles published by the author Alma L. Burlingame from University of California, San Francisco in the year 2013. The author has contributed to research in topic(s): Mass spectrometry & Phosphorylation. The author has an hindex of 107, co-authored 610 publication(s) receiving 43486 citation(s). Previous affiliations of Alma L. … daughterly clearcareonlineWeb12 Dec 2013 · SHOC2 KD leads to a strong inhibition of EGF-induced ERK phosphorylation. In contrast, SCRIB KD leads to a modest increase in ERK phosphorylation by 10 min that … daughter love knotWebThe .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. b-k medical medizinische systeme gmbhWeb16 Dec 2014 · Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited … bkmedicalwingWeb20 Dec 2012 · This mutation resulted in an increase in the magnitude and duration of EGFR phosphorylation and signaling to Extracellular Regulated Kinase 1/2 ... Both the loss of Shoc2 (by RNAi) and certain mutants of Shoc2 that lead to membrane targeting result in decreased ERK1/2 activity . These data provide strong evidence that Shoc2 is a spatial … daughter love noteWeb1 Mar 2024 · The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. ... bk medical fdaWeb12 Mar 2024 · Whether and how FBXW7 regulates these two oncogenic pathways are unknown. Here, we showed that SHOC2, a RAS activator, is a FBXW7 substrate. Growth … daughter losing a father poem