Jph2 molecular weight

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NettetJPH2 has 2,942 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 72 datasets. NettetJPH2_ENST00000342272 Sequences You can see various sequences for this gene: cDNA (ENST00000372980.3) Protein (JPH2) Transcript and protein aligned …

JPH2 junctophilin 2 [Homo sapiens (human)] - Gene - NCBI

Nettet13. aug. 2012 · Several molecular mechanisms have been shown to contribute to downregulation of JPH2 expression levels in failing hearts (28,272). First, the mouse, rat, and human homologues of JPH2 are... Nettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. JPH2 is believed to keep the plasma ... mason mi city hall

Anti-JP-2 antibody (ab79071) Abcam

Nettet7. jan. 2011 · The critical role of this protein in maintaining the precise subsarcolemmal geometry needed for CICR is underscored by the embryonic lethality of JPH2-deficient mice stemming from altered dyadic ultrastructure and stochastic Ca 2+ transients with reduced amplitude. 19 Loss of JPH2 expression was observed in rodent models of … Nettet28. aug. 2024 · The number average molecular weight (M n) is given by 2.2.7 , where M i is molecular weight of a molecule of oligomer n, and N i is number of molecules of that molecular weight. Total weight = Σ ∞ i = 1MiNi. Total number = Σ ∞ i = 1Ni. Mn = Σ ∞ i = 1MiNi Σ ∞ i = 1Ni. Example 2.2.8. NettetThe molecular weight distribution (MWD) is conveniently characterized by either the number N(n) or weight W(n) of chains with n repeating units (e.g., a chain with molecular weight M = nm0 with m0 the molar weight of a repeating unit). The normalized functions N — (n) = N(n)/ΣN(n) (1) N — (n) = W(n)/ΣW(n) (2) respectively, are the number ... mason mi gun and knife show

59091 - Gene ResultJph2 junctophilin 2 [ (house mouse)]

NettetTwelve 8-week-old male SD rats with a mean weight of 273.7 ± 3.2 g were randomized into two groups: six rats were subjected to saline (Double Crane Pharmaceutical Co. … NettetThe standard atomic weight takes into account the isotopic distribution of the element in a given sample (usually assumed to be "normal"). For example, water has a relative molecular mass of 18.0153 (3), but individual water molecules have molecular masses which range between 18.010 564 6863 (15) Da ( 1 H 216 O) and 22.027 7364 (9) Da ( … hybrid or cruiser bikeNettetUseful information about the protein provided by UniProt. [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcopl asmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes 1. Provides a structural foundation for functional cross-talk between the ... mason middle school schedule

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Jph2 molecular weight

JPH2 Gene - GeneCards JPH2 Protein JPH2 Antibody

Nettet17. jan. 2003 · HGNC:14202 JPH2 MIM 605267 gene 613873 phenotype 619492 phenotype VEuPathDB HostDB:ENSG00000149596 neXtProt NX_Q9BR39 Subcellular … http://www.chem.cmu.edu/groups/berry/gcbmwd.pdf

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Nettet18. apr. 2007 · Junctophilin-2 (JPH2) is a cardiac specific member of the junctophilins, a newly characterized family of junctional membrane complex proteins important in physically approximating the plasmalemmal L-type calcium channel and the sarcoplasmic reticulum ryanodine receptor for calcium-induced calcium release. NettetMethods and Results—JPH2 expression was reduced in flash-frozen human cardiac tissue procured from patients with HCM compared with ostensibly healthy traumatic death victims. Partial silencing of JPH2 expression in HL-1 cells by a small interfering RNA probe targeted to murine JPH2 mRNA (shJPH2) resulted in myocyte hypertrophy and increased

Nettet30. mar. 2024 · ( G) mRNA expression levels for JPH2 and CAV3. ( H) Protein expression levels determined using JPH2 (sc-51313, Santa Cruz Biotechnology) and CAV3 (ab2912, Abcam) antibodies. n = 5 per group for G and H. * P < 0.05 and ** P < 0.01 vs. the euthermic group by Student’s t test. Open in viewer Increased Expression of JPH2 and … Nettet21. jun. 2024 · Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in …

Nettet1. sep. 2024 · HGNC Approved Gene Symbol: JPH2 Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,106,590-44,187,188 (from NCBI) Gene-Phenotype Relationships PheneGene Graphics TEXT Description Nettet2. mar. 2024 · This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008] Expression. Biased expression in heart (RPKM 14.9), …

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic membrane occupa…

Nettet18. okt. 2024 · Junctophilin 2, as junctional membrane complex (JMC) protein, is an important regulator of the cardiac SK channels RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure loss of nuclear JP2NT function accelerates stress-induced development of hypertrophy and heart failure in mutant mice hybrid packNettetJPH2 Junctophilin-2: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. ... Molecular weight: 74,222 Da hybrid pack sicNettetJPH2 is a hot spot for mutations linked to hypertrophic cardiomyopathy (HCM) ( 15 – 17 ), and repeats in JPH3 have been found to cause Huntington disease-like 2 (HDL-2) ( 18 ). In addition, cardiac stress results in activation of calpain, which cleaves JPH2 and drives heart failure progression ( 19 – 24 ). hybrid pack 2NettetConstruction of a sulfonation modification system for preparation of heparins having different molecular weights, and an application thereof, relating to the technical field of bioengineering. By means of synthetic biological technology and genetic engineering means, and by using Pichia pastoris GS115 as a starting strain, heparin synthesis … hybrid pack 1Nettet15. jun. 2014 · JPH2 has emerged as a critical regulator of the complex JMC microenvironment in cardiac myocytes. It provides an anchor for developing T-tubules … hybrid paintball shirtsNettetView Mouse Monoclonal anti-JPH2 Antibody (OTI1F5) (NBP2-45469). Validated Applications: WB, ICC/IF. Validated Species: Human, Mouse, Rat. Skip to main content ... The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, … hybrid paintNettet9. aug. 2010 · Junctophilin-2 (JPH2) is a membrane-binding protein that plays a key role in the organization of the junctional membrane complex (JMC) in cardiac myocytes. hybrid page replacement algorithm