WebBackground. Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. WebNov 11, 2024 · 2.1 Cardiac Properties of the Vasostatin-Derived Chromofungin. Within the VS-1 domain, a cardiovascular function was recently described for the fragment 47–66. It was identified by Lugardon and collegues in 2001, and named chromofungin (Chr) for its antifungal activity, was identified by Lugardon and collegues (Lugardon et al. 2001).

A systematic review of chromogranin A (CgA) and its biomedical ...

WebNov 1, 2005 · Chromofungin (Chf) was synthesized by Dr M.H. Metz-Boutigue (Inserm U575) and provided in dehydrated form, with the following sequence: RILSILRHQNLLKELQDLAL. The peptide has a pHi of 10.8, the protein is positively charged at our working pH (6.5) which implies to adsorb it onto a negative layer. WebNew endogenous antimicrobial peptides (AMPs) derived from chromogranin A (CgA) are secreted by nervous, endocrine and immune cells during stress. They display antimicrobial activities by lytic effects at micromolar range using a pore-forming mechanism against Gram-positive bacteria, filamentous fungi and yeasts. inconsistency\\u0027s pd

Pharmaceutics Free Full-Text Chromogranin A and Its Fragments …

The most active shortest peptide, named chromofungin, corresponds to the sequence Arg47–Leu66. Extensive1H NMR analysis revealed that it adopts a helical structure. The biophysical mechanism implicated in the interaction of chromofungin with fungi and yeast cells was studied, showing the penetration of this peptide with different lipid ... WebChromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and … WebThis gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. incidence of whooping cough